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This review examines the link between diabetes and neurodegenerative diseases, explores the effects of antidiabetic agents on neurodegeneration, provides a concise overview of the GLP-1 pathway, and discusses both preclinical and clinical trial outcomes of GLP-1RAs for neurodegenerative diseases, including their effects on cognition in AD and PD

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Patients should be counseled on warning signs including inability to tolerate oral fluids, decreased urine output, dizziness, or severe abdominal pain, which require immediate medical evaluation rather than dose escalation

That same year, Zafgen demonstrated beloranibs efficacy, a MetAP2 inhibitor, in a Phase III trial, but safety concerns ultimately led to its discontinuation

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